mastocytosis
Mastocytosis is a group of rare disorders of both children and adults caused by the presence of too many mast cells (mastocytes) and CD34 + mast cell precursors in a person’s body. [1]
Mastocytosis is a rare disorder characterized by abnormal accumulations of mast cells in skin, bone marrow, and internal organs such as the liver, spleen and lymph nodes. [2]
Mastocytosis is a disease characterized by the presence of too many mast cells in various organs and tissues. [3]
Mastocytosis is an uncommon condition in which there is an abnormal increase in mast cells in various organs, most commonly the skin. [4]
Mastocytosis: A disorder where excessive amounts of mast cells proliferate in organs such as the skin, liver, bone, spleen and gastrointestinal tract. [5]
Most cases produce symptoms but do not shorten life expectancy. [3]
The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. [2]
Mastocytosis is an uncommon abnormal accumulation of mast cells in the skin and sometimes in various other parts of the body. [6]
No one is sure how many people have either type of mastocytosis, but mastocytosis generally has been considered to be an “orphan disease ” (orphan diseases affect 200,000 or fewer people in the United States). [3]
Other substances that lead to mastocytosis symptoms include histamine (see above), heparin (a blood thinner), prostaglandins, acid hydrolases, and neutral proteases. [4]
Mastocytosis may affect primarily the skin (called cutaneous mastocytosis) or other parts of the body (called systemic mastocytosis). [6]
More detailed information about the symptoms, causes, and treatments of Mastocytosis is available below. [5]
When there is evidence of bone marrow or internal organ involvement, the disease is referred to as “systemic mastocytosis”. [2]
In laboratory studies, scf appears to be important for the proliferation of mast cells, and inhibiting the tyrosine kinase receptor with imatinib (see below) may reduce the symptoms of mastocytosis. [1]
Mast cells are found primarily in the skin and digestive system, including the liver and spleen, and produce histamine, a chemical most famous for its ability to cause itching. [3]
Sources:
[1] Mastocytosis - Wikipedia, the free encyclopedia
[2] Mastocytosis
[3] Mastocytosis: Definition from Answers.com
[4] MedFriendly.com: Mastocytosis
[5] Mastocytosis - WrongDiagnosis.com
[6] Mastocytosis: Allergic Reactions: Merck Manual Home Edition